How is it possible that drugs used to sedate or calm people, called Benzodiazepines, can induce transient awakenings in comatose patients? In our latest Commentary in Translational Medicine Communications Yehezkel Ben-Ari hypothesizes that a dysregulation of GABAergic activity underlies this seemingly contradictory effect. Extensive experimental work suggests that after brain damage and a large variety … Sleeping pills that cause “awakenings”?
Since our groundbreaking positive results on the use of Bumetanide (a highly selective antagonist of the NKCC1 chloride importer) to treat autism, first in a pilot open trial and then in two double-blind clinical trials, numerous independent trials have confirmed these results. A new report by Christopher Gillberg’s group in Sweden (addressed in our recent … A new report on the promising use of Bumetanide treatment for autism
Huntington’s disease, a dominant heritable disease that manifests in mid-adulthood, is caused by expansion of a polyglutamine tract within the huntingtin protein (HTT). The mutation leading to the polyglutamine tract confers a toxic gain of function phenotype resulting in neurodegeneration that is most severe in the striatum. Despite its “late” symptomatic manifestation, there are several … A Huntington’s disease study supporting the Neuroarcheology concept