News


The latest news, selected media, press releases, scientific articles and literature review from Neurochlore.

Servier and Neurochlore announce the main results of the two phase 3 clinical studies assessing bumetanide in the treatment of Autism Spectrum Disorders in children and adolescents

Servier and Neurochlore announce the main results of the two phase 3 clinical studies assessing bumetanide in the treatment of Autism Spectrum Disorders in children and adolescents

Press Releases
PR-Servier-Neurochlore-Bumetanide Phase 3 ResultsTélécharger
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Smaller brain volumes after birth by Cesarean Section

Smaller brain volumes after birth by Cesarean Section

Scientific papers
Being born is not easy. Mammals need to pass through the birth canal before coming out into this world, and to do so the head (and whole body) undergoes a harsh squeezing. Thankfully, the newborn...
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Sleeping pills that cause “awakenings”?

Sleeping pills that cause “awakenings”?

Literature Review
How is it possible that drugs used to sedate or calm people, called Benzodiazepines, can induce transient awakenings in comatose patients? In our latest Commentary in Translational Medicine Communications Yehezkel Ben-Ari hypothesizes that a dysregulation...
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A new report on the promising use of Bumetanide treatment for autism

A new report on the promising use of Bumetanide treatment for autism

Literature Review
Since our groundbreaking positive results on the use of Bumetanide (a highly selective antagonist of the NKCC1 chloride importer) to treat autism, first in a pilot open trial and then in two double-blind clinical trials,...
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A Huntington’s disease study supporting the Neuroarcheology concept

A Huntington’s disease study supporting the Neuroarcheology concept

Literature Review
Huntington’s disease, a dominant heritable disease that manifests in mid-adulthood, is caused by expansion of a polyglutamine tract within the huntingtin protein (HTT). The mutation leading to the polyglutamine tract confers a toxic gain of...
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The GABA developmental sequence is altered in a mouse model of Rett Syndrome

The GABA developmental sequence is altered in a mouse model of Rett Syndrome

Scientific papers
The activity of the neurotransmitter GABA, the main inhibitory transmitter in the brain, follows a developmental sequence. In early development GABA excites neurons via type A GABA receptors (GABAAR), and later it inhibits them. In...
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No stop-growing signal around birth in a rodent model of autism

No stop-growing signal around birth in a rodent model of autism

Scientific papers
How does the brain prepare for birth? Several indirect lines of evidence in Humans suggest that the velocity at which the brain grows in utero slows down during the third trimester, a process that will...
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Immune activation during gestation leads to hippocampal neuronal alterations already at birth

Immune activation during gestation leads to hippocampal neuronal alterations already at birth

Scientific papers
Two of the most biologically complex and vulnerable periods are pregnancy and birth. Birth is a stressful event with a release of several stress molecules needed to facilitate the transition of the fetus to extrauterine...
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A promising multicenter trial to alleviate autistic disorders

A promising multicenter trial to alleviate autistic disorders

Scientific papers
In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl−)i levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide...
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4e Prize Créa13 2014 : Neurochlore

4e Prize Créa13 2014 : Neurochlore

Awards
Encourage, support and publicize active, innovative companies that create jobs in the industrial and craft fields, these are the objectives set by the General Council of Bouches-du-Rhône, which has been organizing the Créa 13 prize...
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The diuretic Bumetanide and the birth hormone Oxytocin point to a common pathway in the early pathogenesis of Autism in rodents

The diuretic Bumetanide and the birth hormone Oxytocin point to a common pathway in the early pathogenesis of Autism in rodents

Scientific papers
The scientific community agrees on the early origin – fetal and/or early postnatal – of autism. The teams of Yehezkel Ben-Ari (CEO of Neurochlore and Emeritus Research Director at Inserm) at Neurochlore and at the...
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Economics Trophies: 1st prize in the category: “Tremplins La Provence”

Economics Trophies: 1st prize in the category: “Tremplins La Provence”

Awards
Voir la page de l'article de La Provence
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Treating Fragile X syndrome with the diuretic bumetanide: a case report

Treating Fragile X syndrome with the diuretic bumetanide: a case report

Scientific papers
We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment. In...
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A randomised controlled trial of bumetanide in the treatment of autism in children

A randomised controlled trial of bumetanide in the treatment of autism in children

Scientific papers
Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA excites neurons because...
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The GABA excitatory/inhibitory shift in brain maturation and neurological disorders

The GABA excitatory/inhibitory shift in brain maturation and neurological disorders

Scientific papers
Ionic currents and the network-driven patterns they generate differ in immature and adult neurons: The developing brain is not a "small adult brain." One of the most investigated examples is the developmentally regulated shift of...
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