Treating Fragile X syndrome with the diuretic bumetanide: a case report

Scientific papers  |  10 June 2013

We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment. In keeping with extensive clinical use of this diuretic, the only side effect was a small hypokalaemia. A double-blind clinical trial is warranted to test the efficacy of bumetanide in FRX.

Eric Lemonnier  1 Gaëlle RobinCéline DegrezRoman TyzioMarine GrandgeorgeYehezkel Ben-Ari