Being born is not easy. Mammals need to pass through the birth canal before coming out into this world, and to do so the head (and whole body) undergoes a harsh squeezing. Thankfully, the newborn prepares for this stressful event that transitions life from in-utero to ex-utero. But these events (some, or all of them) Smaller brain volumes after birth by Cesarean Section

How is it possible that drugs used to sedate or calm people, called Benzodiazepines, can induce transient awakenings in comatose patients? In our latest Commentary in Translational Medicine Communications Yehezkel Ben-Ari hypothesizes that a dysregulation of GABAergic activity underlies this seemingly contradictory effect. Extensive experimental work suggests that after brain damage and a large variety Sleeping pills that cause “awakenings”?

Since our groundbreaking positive results on the use of Bumetanide (a highly selective antagonist of the NKCC1 chloride importer) to treat autism, first in a pilot open trial and then in two double-blind clinical trials, numerous independent trials have confirmed these results. A new report by Christopher Gillberg’s group in Sweden (addressed in our recent A new report on the promising use of Bumetanide treatment for autism

Huntington’s disease, a dominant heritable disease that manifests in mid-adulthood, is caused by expansion of a polyglutamine tract within the huntingtin protein (HTT). The mutation leading to the polyglutamine tract confers a toxic gain of function phenotype resulting in neurodegeneration that is most severe in the striatum. Despite its “late” symptomatic manifestation, there are several A Huntington’s disease study supporting the Neuroarcheology concept

The activity of the neurotransmitter GABA, the main inhibitory transmitter in the brain, follows a developmental sequence. In early development GABA excites neurons via type A GABA receptors (GABAAR), and later it inhibits them. In addition, during the critical period of birth, as a protective mechanism, GABA becomes temporarily inhibitory. Five years ago, we showed The GABA developmental sequence is altered in a mouse model of Rett Syndrome

How does the brain prepare for birth? Several indirect lines of evidence in Humans suggest that the velocity at which the brain grows in utero slows down during the third trimester, a process that will make sense knowing that the head should be able to fit through the birth canal during delivery. In our recent No stop-growing signal around birth in a rodent model of autism

Two of the most biologically complex and vulnerable periods are pregnancy and birth. Birth is a stressful event with a release of several stress molecules needed to facilitate the transition of the fetus to extrauterine life. Furthermore, throughout pregnancy the fetus is susceptible to different types of stressors including immune activation due to maternal infections Immune activation during gestation leads to hippocampal neuronal alterations already at birth

In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl−)i levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide reduced the severity of ASD in children and adolescents (3–11 years old). Here we report the results of a multicentre A promising multicenter trial to alleviate autistic disorders

Encourage, support and publicize active, innovative companies that create jobs in the industrial and craft fields, these are the objectives set by the General Council of Bouches-du-Rhône, which has been organizing the Créa 13 prize since 1992, and since 2001. in partnership with the Airbus Helicopters Group. Neurochlore won the 4th prize of the 2014 4e Prize Créa13 2014 : Neurochlore

The scientific community agrees on the early origin – fetal and/or early postnatal – of autism. The teams of Yehezkel Ben-Ari (CEO of Neurochlore and Emeritus Research Director at Inserm) at Neurochlore and at the Mediterranean Neurobiology Institute (Inmed), have just taken a new step in understanding the early manifestations of the disease. The researchers The diuretic Bumetanide and the birth hormone Oxytocin point to a common pathway in the early pathogenesis of Autism in rodents